Best Allergy Medicine for Ragweed

In my experience, the best allergy medicine for ragweed allergies is Claritin® (Loratadine). But, the best allergy medicine for your ragweed allergy symptoms may be different. Let me explain why this is my #1 choice, and what I thought about the other antihistamines on the market.

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Best over-the-counter antihistamine for ragweed

I have had ragweed allergies for over 30 years and have tried just about all the OTC antihistamines. The medication that I keep going back to, and currently take today is Claritin, and here is why.



Claritin® (Loratadine) has not steered me wrong through the years and has been providing me with seasonal allergy relief for at least 16 years strong. The symptoms this medication has helped me out with the most are sneezing, itchy eyes, and hives.

What I like about Claritin:

  • Available OTC
  • No side effects (for me)
  • Non-drowsy
  • Eases my allergy symptoms
  • Lasts 24-hours

With daily use of the powerful tablets, you could finally have fast, 24-hour relief from those pesky allergies so you can get on with life without all the interruptions.

No more sneezing during meetings or itchy eyes keeping you up at night! Head over to Amazon and check it out.

prescription bottle with a yellow label for loratadine, known as Claritin®. Label says: take one tablet by mouth every day for allergy, quantity 90

You may also be able to get it prescribed to you by your primary care manager and have your insurance cover it.

Great ragweed allergy medications

There can only be one “best” ragweed antihistamine, and in my personal opinion that is Claritin. These additional antihistamines might not be my number one choice, but they could very well be the ones that work best for you.



Zyrtec® (Cetirizine Hydrochloride) is a super close “2nd place” to my Claritin pick. Off and on through the years, I will try a different allergy medication, and Zyrtec is always the one I retry first. Unfortunately, there are always these reasons I am unable to take Zyrtec long-term.

  • Gives me a headache
  • Constant dry mouth
  • Not as effective

I think it is important to note that if Claritin did not exist, I would take Zyrtec as my main ragweed antihistamine.

Zyrtec is close in price to Claritin and can also be found on Amazon.



I have tried Allegra® (Fexofenadine) a few times throughout the years, and my results seemed to vary. I had Allegra prescribed to me and was on the medication for the fall allergy season.

When I first started taking Allegra I remember being nauseous with a loss of appetite for a few weeks.

My allergy symptom relief was good, and I do not recall being drowsy on it. After sharing my experience with my doctor, they ended up switching me to a different medication.



My antihistamine journey began with Benedryl® (Diphenhydramine) when I was a child, mostly because no other antihistamines existed yet.

Benedryl is the “OG” of ragweed OTCs and is still a valid choice for allergies today.

I like Benedryl because it works really well, but its performance comes at a price. Drowsiness. In my experience, no matter how long you take the medication, you will get sleepy.

All of these antihistamines are in the “ragweed medication big leagues”, and are similar in performance. Talk with your doctor and discuss what the best treatment option is for you.

More ragweed allergy information

Check out our in-depth ragweed allergy article for additional treatment and avoidance information on ragweed allergies.

By Chris

Chris is the creator of Allergy Preventions. As an allergy sufferer himself, his vision is to help others find relief from allergies. By combining his 14 years of Public Health experience, personal experience, and his thirst for knowledge, he is dedicated to providing quality recommendations to assist families with allergy symptom relief.